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Taking the antimalarial drughydroxychloroquinedid not prevent mass from coming down with COVID-19 after being expose to the disease , fit in to a new subject area .
The survey , publish Wednesday ( June 3 ) in theNew England Journal of Medicine , is the first of its kind to examine Plaquenil as a elbow room to foreclose COVID-19 , rather than to treat it in mass who are already sick with the disease , allot toThe Washington Post .
Hydroxychloroquine has gained attention in late months after President Donald Trump called it a potential " game changer " and expose he had take it for several days as a style to protect against COVID-19 infection , despite a want of evidence that it bring for this purpose , the Post reported .
The study findings are " not surprising given that there has not been efficacy established for this drug in any meaningful way of life " for COVID-19 , Dr. Eric Topol , director of the Scripps Research Translational Institute in San Diego , who was not involved in the discipline , severalize the Post .
The Modern study , from research worker at the University of Minnesota , involved 821 people who were expose to a individual withCOVID-19 , either because they were a healthcare prole or because someone in their household tested positive for the disease . The participants were haphazardly assigned to get Plaquenil or a placebo within four days of their exposure . The subject area was " three-fold blind , " meaning that neither the doctor nor the participants knew which group they were depute to .
After two weeks , about 12 % of participants in the Plaquenil group developed symptoms of COVID-19 compare with 14 % of participants in the placebo group , a difference that was too small to be meaningful or " statistically pregnant . "
The bailiwick also found that about 40 % of mass in the hydroxychloroquine group experience side effects , most commonly sickness , upset stomach anddiarrhea , compared with 16 % in the placebo group . No serious side effects , such as heart complications , were report . ( Other study have raised rubber issues with this class of drug . For example , a Brazilian study testing the related drug chloroquine for COVID-19 had to be stopped too soon after some affected role taking high dose of the drug make grow grave pith musical rhythm problems , Live Science antecedently reported . )
One limitation of the novel work is that , when it began in mid - March , COVID-19 examination in the U.S. was not widely approachable , and so the work was not able to broadly speaking check for symptomless cases of COVID-19 . Instead , most participants were diagnosed base on symptoms alone , with only about 15 % of cases being confirmed with a science laboratory exam . Still , the authors observe that because the study was randomized , other malady that could not be ruled out ( such as grippe ) , should have been as distributed between the two groups .
In addition , study participants tended to be relatively immature ( the ordinary eld was 40 years old ) , and it ’s unreadable whether Plaquenil would have more of a benefit for high - risk groups such as old adults , the authors say .
Originally published onLive skill .
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